Mix and match: New 3-D cell culture model replicates fibrotic elements of pancreatic cancer

Pancreatic cancer is a life-threatening disease with very poor survival rates in patients, and—despite various efforts—its treatment remains challenging. This is because pancreatic cancer is characterized by the presence of ‘fibrosis,’ a pathological scarring process that occurs when the physiological wound healing process goes awry. Thus, to tackle pancreatic cancer, it is crucial to understand the mechanisms driving fibrosis in detail. However, experimental models that are used to study pancreatic cancer have not yet been able to fully replicate the extent of fibrosis in human tissue.